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Extra resources for Acute Myelogenous Leukemia (Contemporary Hematology)
Many of the genetic changes that affect C/EBPa occur in separate AML subsets: flt3ITD is less common in CBF leukemias or in AMLs with CIEBPa mutations, CBF~-SMMHC is associated with FAB M4 cases, whereas CEBPA mutation is more common in FAB M2 AMLs, and AMLl-ETO and C/EBPa point mutations are found to be mutually exclusive in FAB M2 cases. Interestingly, t(8;21), inv(l6), and C/EBPa gene mutations are each considered to be favorable prognostic features of AML, further suggesting a mechanistic link among these leukemia subsets (110-112).
Treatment of poor prognosis AML patients using PSC833 (valspodar) plus mitoxantrone, etoposide, and cytarabine (PSC-MEC). Adv Exp Med Bioi 1999;457:47-56. 172. Baer MR, George SL, Dodge RK, et al. Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B Study 9720. Blood 2002;100:1224-1232. 173. Kolitz JE, George SL, Dodge RK, et al. Cancer and Leukemia Group B. Dose escalation studies of cytarabine, daunorubicin, and etoposide with and without multidrug resistance modulation with PSC-833 in untreated adults with acute myeloid leukemia younger than 60 years: final induction results of Cancer and Leukemia Group B Study 9621.
Nature 2000;404:193-197. 2. Traver D, Miyamoto T, Christensen J, Iwasaki-Arai J, Akashi K, Weissman IL. Fetal liver myelopoiesis occurs through distinct, prospectively iso1atable progenitor subsets. Blood 2001;98:627-635. 3. Friedman AD. Transcriptional regulation of granulocyte and monocyte development. Oncogene 2002; 1:3377-3390. 4. Crispino JD. GATA1 in normal and malignant hematopoiesis. Semin Cell Dev Bioi 2005;16:137-147. 5. Abramovich C, Humphries RK. Hox regulation of normal and leukemic hematopoietic stem cells.