Acute Myelogenous Leukemia (Contemporary Hematology) by Judith E. Karp

By Judith E. Karp

This is a well timed compilation of latest techniques within the molecular pathogenesis and molecular treatment of acute myelogenous leukemia (AML). the focal point is on chosen serious molecular determinants of AML pathogenesis and pathophysiology and the exploitation of those elements through varied healing brokers and modalities. there's an emphasis all through at the bidirectional circulation of information among the medical and laboratory arenas.

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Many of the genetic changes that affect C/EBPa occur in separate AML subsets: flt3ITD is less common in CBF leukemias or in AMLs with CIEBPa mutations, CBF~-SMMHC is associated with FAB M4 cases, whereas CEBPA mutation is more common in FAB M2 AMLs, and AMLl-ETO and C/EBPa point mutations are found to be mutually exclusive in FAB M2 cases. Interestingly, t(8;21), inv(l6), and C/EBPa gene mutations are each considered to be favorable prognostic features of AML, further suggesting a mechanistic link among these leukemia subsets (110-112).

Treatment of poor prognosis AML patients using PSC833 (valspodar) plus mitoxantrone, etoposide, and cytarabine (PSC-MEC). Adv Exp Med Bioi 1999;457:47-56. 172. Baer MR, George SL, Dodge RK, et al. Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B Study 9720. Blood 2002;100:1224-1232. 173. Kolitz JE, George SL, Dodge RK, et al. Cancer and Leukemia Group B. Dose escalation studies of cytarabine, daunorubicin, and etoposide with and without multidrug resistance modulation with PSC-833 in untreated adults with acute myeloid leukemia younger than 60 years: final induction results of Cancer and Leukemia Group B Study 9621.

Nature 2000;404:193-197. 2. Traver D, Miyamoto T, Christensen J, Iwasaki-Arai J, Akashi K, Weissman IL. Fetal liver myelopoiesis occurs through distinct, prospectively iso1atable progenitor subsets. Blood 2001;98:627-635. 3. Friedman AD. Transcriptional regulation of granulocyte and monocyte development. Oncogene 2002; 1:3377-3390. 4. Crispino JD. GATA1 in normal and malignant hematopoiesis. Semin Cell Dev Bioi 2005;16:137-147. 5. Abramovich C, Humphries RK. Hox regulation of normal and leukemic hematopoietic stem cells.

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