Atherothrombosis and Coronary Artery Disease by Valentin Fuster MD PhD, Eric J. Topol MD, Elizabeth G.

By Valentin Fuster MD PhD, Eric J. Topol MD, Elizabeth G. Nabel MD

Written by way of the world’s most advantageous gurus, this quantity presents complete assurance of present techniques to the prevention, analysis, and administration of atherothrombosis and its coronary and noncoronary problems. This version has been completely up to date, sharply thinking about scientific info, and trimmed to at least one conceivable volume.

Coverage starts off with a assessment of threat elements and prevention, emphasizing lipid abnormalities, high blood pressure, smoking, diabetes, and weight problems. next sections learn the pathogenesis of atherosclerosis, markers and imaging, acute coronary syndromes, persistent sturdy angina, and noncoronary atherothrombosis. medical displays, clinical administration, and the most recent interventional techniques are included.

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Sample text

An inquiry into the symptoms and causes of the syncope anginosa commonly called angina pectoris. Bath, England: R. Cruttwell, 1799. 29. Burns A. Observations on some of the most frequent and important diseases of the heart. Edinburgh: Bryce & Co, 1809. 30. Fye WB. T. Lauder Brunton and amyl nitrite: a Victorian vasodilator. Circulation 1986;74:222–229. 31. Fye WB. Nitroglycerin: a homeopathic remedy. Circulation 1986;73: 21–29. 32. Fye WB. The delayed diagnosis of acute myocardial infarction: it took half a century.

Heart disease. New York: Macmillan, 1931. 18. Tillett WS, Garner RL. The fibrinolytic activity of hemolytic streptococci. J Exp Med 1933;58:485–502. 19. Ahrens EH Jr. The crisis in clinical research: overcoming institutional obstacles. New York: Oxford University Press, 1992. 20. Keele KD. Leonardo da Vinci on the movement of the heart and blood. London: Harvey and Blythe Ltd, 1952. 21. Bedford DE. Harvey’s third circulation. De circulo sanguinis in corde. Br Med J 1968;4:273–277. 22. Fye WB. Coronary arteriography: it took a long time.

Gradually, clinicians acknowledged that acute coronary thrombosis was not invariably fatal, but there was no recognition of the clinical syndrome of acute myocardial infarction until Russian physicians W. P. Obrastzow and N. D. Straschesko published the first description of this dramatic event in 1910. They believed that two specific findings were characteristic of acute coronary thrombosis: prolonged chest discomfort (“status anginosus”) and persistent dyspnea (“status dyspnoeticus”). After presenting cases with autopsy correlations, Obrastzow and Straschesko concluded that “the differential diagnosis of coronary thrombosis from angina pectoris is made by the presence of status anginosus with coronary thrombosis and its absence with isolated attacks of angina pectoris” (37,38).

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