Atrial Septal Defect by P. Rao

By P. Rao

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2. Risk to the offspring from pregnancy in women with ASD compared to women with other congenital heart diseases. (Reproduced with permission. Drenthen et al 2007). 8. Contraception Pregnancy is not contraindicated in women with ASD. However, there may be social and other clinical circumstances that may require delaying ASD closure and therefore, the pregnancy. In such circumstances, conception may be used. Since ASD is an acyanotic heart disease, there are more options compared to women with cyanotic heart disease.

1994). The clinical and genetic spectrum of the Holt-Oram syndrome (heart-hand syndrome). N Engl J Med 330:885-889. 36 Atrial Septal Defect Benson DW, Silberbach GM, Kavanaugh-McHugh A, Cottrill C, Zhang Y, et al. (1999). 5 affect diverse cardiac developmental pathways. J Clin Invest 104:1567-1573. Boldt T, Anderson S, Eronen M. (2002). Outcome of structural heart disease diagnosed in utero. Scand Cardiovasc J. 36:73-79. Botto LD, Lin AE, Riehle-Colarusso T, Malik S, Correa A, and the National Birth Defects Prevention Study.

There is a mild increase in respiratory rate. Functional residual capacity increases by approximately 40% (Perloff, JK et al. 1992). 3 Hematologic changes Due to hormonal changes, blood volume increases to about 150% of the pre-gestational value (Figure 1). This is accomplished by increase in plasma volume out of proportion to the increase in red cell mass. Therefore, “physiologic” anemia occurs which in turn imposes a hyperdynamic circulatory state (Figure 1). Fig. 1. Hematologic changes during pregnancy.

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