By Kenneth J. Carpenter
Lines the a long time of clinical & chemical study that solved the puzzle posed via beriberi, a mysterious sickness that's as a result of the inability of a minute volume of the chemical thiamin, or nutrition B1, within the nutrition. Western medical professionals operating in Asia after 1870 observed it because the significant affliction between those that ate white rice, whereas humans consuming brown rice, the place the grain nonetheless contained its bran & germ, remained fit. examine ultimately enabled the synthesis of ''thiamin'', that's now used to complement white rice & flour in such a lot complicated nations, yet no longer in poorer international locations the place the sickness has been endemic. ''A attention-grabbing chronicle of a historical past that encompasses public healthiness, technological know-how, vitamin, exchange, increasing empires, conflict, & technology.'' Illustrations.
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Additional info for Beriberi, White Rice and Vitamin B: A Disease, a Cause, and a Cure
There was no fume hood, but there was another little annex that carried a stone water basin which fed the two water taps in the lab and, by adding a door, it made a closet. This was ﬁtted with a gas pipe which made it possible to heat six to eight Kjeldahl ﬂasks. 64 VORDERMAN’S PRISON STUDY Eijkman still had no direct evidence that his ﬁndings with chickens had any relevance to the human disease. 65 He was fourteen years older than Eijkman and had already served in the East Indies for nearly twenty years, ﬁrst in the navy, and now in the civil government, where he was inspector of prisons for the whole of Java, which is about nine hundred miles long and one hundred miles wide, with roughly the area of Greece.
Now, of course, these islands form the bulk of an independent Indonesia. It is from there that we have the ﬁrst published reference to beriberi by a Westerner, Jacob de Bont, a physician who went to Java in 1637 and died there only four years later at the age of thirty-nine. 2 He described sufferers 24 Studies in the Colonies 25 KOREA Yedo Nanking JAPAN Nagasaki Shanghai CHINA BENGAL INDIA Canton BURMA Rangoon SIAM Bangkok Manila INDO– CHINA CEYLON FORMOSA Hong Kong PACIFIC OCEAN PHILIPPINE ISLANDS Saigon Atjeh MALAYA Singapore M SU Ternate RA AT BORNEO U D INDIAN OCEAN TC Batavia H EA ST IN D CELEBES MOLUCCA ISLANDS NEW GUINEA IES JAVA AUSTRALIA Fig.
Control chickens, housed separately, still became diseased, so direct contact was unnecessary. The whole premises might be contaminated, although no characteristic bacteria were isolated. 3. Were the laboratory premises infected? New location selected for additional experiments, but even in the old premises the disease now disappeared. 4. Was it the recent change in the chickens’ diet that was important? Yes, chickens fed leftover cooked hospital rice became diseased, while those fed uncooked feed-grade rice did not.