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Several lipids have been crystallised and their high resolution structure determined, but to date we know of only two integral membrane proteins, matrix porin (Garavito and Rosenbusch, 1980) and reaction centre from Rhodopseudomonas viridis (Michel, 1982), that have been crystallised in forms suitable for high resolution X-ray crystallography. The problem of obtaining crystals is undoubtedly related to the fact that integral membrane components are in contact with both polar and non-polar phases in the intact membrane .
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