Cell Cycle Control: Mechanisms and Protocols (Methods in by Tim Humphrey, Gavin Brooks

By Tim Humphrey, Gavin Brooks

The basic query of ways cells develop and divide has confused biologists because the improvement of the mobilephone concept within the mid-19th century, whilst it was once well-known by means of Virchow and others that “all cells come from cells.” in recent times, huge attempt has been utilized to the identity of the elemental molecules and mechanisms that keep an eye on the telephone cycle in a couple of diverse organisms. Such experiences have resulted in the elucidation of the important paradigms that underpin eukaryotic phone cycle regulate, for which Lee Hartwell, Tim Hunt, and Paul Nurse have been together presented the Nobel Prize for medication and body structure in 2001 in popularity in their seminal contributions to this box. the significance of figuring out the elemental mechanisms that modulate telephone department has been reiterated by means of really fresh discoveries of hyperlinks among cellphone cycle regulate and DNA fix, development, mobile metabolism, improvement, and cellphone dying. This new part of built-in mobilephone cycle learn presents extra demanding situations and possibilities to the organic and clinical worlds in making use of those easy innovations to realizing the etiology of melanoma and different proliferative illnesses.

Show description

Read Online or Download Cell Cycle Control: Mechanisms and Protocols (Methods in Molecular Biology) PDF

Best molecular biology books

An Introduction to Genetic Engineering (Studies in Biology)

The writer provides a easy creation to the area of genetic engineering. a few two decades have handed because the first recombinant DNA molecules have been built at Stanford collage. Genetic engineering is now a truth and this booklet easily and concisely describes to the coed the total variety of allowing applied sciences to be had.

Transformations of Lamarckism: From Subtle Fluids to Molecular Biology (Vienna Series in Theoretical Biology)

In 1809 -- the 12 months of Charles Darwin's beginning -- Jean-Baptiste Lamarck released Philosophie zoologique, the 1st complete and systematic concept of organic evolution. The Lamarckian procedure emphasizes the new release of developmental diversifications; Darwinism stresses choice. Lamarck's rules have been finally eclipsed through Darwinian innovations, particularly after the emergence of the fashionable Synthesis within the 20th century.

Handbook of Epigenetics: The New Molecular and Medical Genetics

Epigenetics is taken into account by way of many to be the "new genetics" end result of the overwhelming proof of the contribution of non-genetic elements corresponding to nutrients, surroundings, and chemical publicity on gene expression. the results of epigenetics are large, together with tissue/organ regeneration, X-chromosome inactivation, and stem mobile differentiation and genomic imprinting and getting older.

Molecular Biology of the Cell 6E - The Problems Book

The issues e-book is helping scholars savour the ways that experiments and easy calculations can result in an knowing of ways cells paintings through introducing the experimental starting place of mobilephone and molecular biology. every one bankruptcy reports keywords, checks for knowing uncomplicated techniques, and poses research-based difficulties.

Additional resources for Cell Cycle Control: Mechanisms and Protocols (Methods in Molecular Biology)

Sample text

Microtubule motors and other associated proteins (MAPs) are required for spindle assembly and function, but many plant MAPs have been isolated that show little homology to animal MAPs. MAP65 proteins bind to subsets of interphase and mitotic microtubule arrays and bundle microtubules in vitro (69–71). These proteins belong to a small gene family that shares a remote ancestor with a yeast protein involved in cytokinesis (72) but have diversified in plants and perhaps acquired new functions. Many of the kinesin related proteins, whose function has been investigated, seem to have a role in phragmoplast formation rather than spindle movements.

And Doonan, J. H. (1994) Patterns of cell division revealed by transcriptional regulation of genes during the cell cycle in plants. EMBO J. 13, 616–624. 38. , et al. (2001) G2/M-phase-specific transcription during the plant cell cycle is mediated by c-Myb-like transcription factors. Plant Cell 13, 1891–1905. 39. , Hou, D. , Ishii, S. (2002) Myb controls G(2)/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc. EMBO J. 21, 675–684. 40. Starr, D. , Williams, B. , Dawe, R.

1. The microtubule cycle in plant cells as revealed by indirect immunofluorescence. The interphase microtubule array, organized as bundles of microtubules in the cortex, gives way in G2 to the preprophase band, which marks the site of cell division. The mitotic spindle has broad poles with several foci. The phragmoplast, involved in cell plate deposition during cytokinesis, is composed of a double ring of antiparallel microtubules. 1. The Microtubule Cycle: Entry Into Mitosis Microtubules undergo dramatic reorganization during the cell cycle, as illustrated in Fig.

Download PDF sample

Rated 4.46 of 5 – based on 41 votes