Colombo's Tips & Tricks for Drug Eluting Stents by Antonio Colombo, Goran Stankovic

By Antonio Colombo, Goran Stankovic

A trailblazer in interventional cardiology, Dr. Antonio Colombo combines his great event with that of Goran Stankovic and unique colleagues to percentage tips and methods for facing diseased coronary arteries. no matter if discussing his 'crushing and kissing' thoughts or the stenting of tortuous vessels within the aged, Dr. Colombo and his colleagues' texts and case commentaries give you the reader with succinct and easy recommendation according to own event. they supply the main complete and sensible advisor to be had for these concerned about coronary artery stenting. the pictures are all down-loadable in Powerpoint and may be of large use to teachers and scholars alike.

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Extra resources for Colombo's Tips & Tricks for Drug Eluting Stents

Sample text

Importantly, the dose of paclitaxel selected for the Taxus Program allows complete endothelial coverage of the stent struts, thus reducing the likelihood of late stent thrombosis (slide 5). Scanning electron micrographs confirm the uniform endothelium with minimal platelet and leukocyte adhesion (slide 6).  By altering the polymer, the amount and pattern of paclitaxel release can be modified (slide 7).  The moderate release (MR) formulation, which is currently under investigation, Page 12 delivers a three times higher local drug dose and was used in Taxus VI, and was compared with the SR formulation in Taxus II (slide 8).

Detailed 6­month assessment with Optical Coherence Tomography (OCT) demonstrated the typical ‘stent­within­a­stent’ appearance, and the neointima formation within the drug­eluting stent can be clearly seen, thus reducing the likelihood of late stent thrombosis from exposed stent struts (slide 27). Taxus IV (slide 28). 75 mm (slide 29). TLR fell significantly in the Taxus treated patients at 9 months angiographic follow­up (slide 30, Figure 4). 7% (slide 31, Figure 5). In the Taxus group, TLR was independent of lesion length or reference vessel diameter (slide 32).

This improvement occurred despite the fact that the lesions in the ‘new’ SIRIUS were located in the vessels with the small reference size (slide 5).  The use of long stents is most probably an explanation for this finding (slide 6).  This, of course, applies to lesions suitable for this approach (slide 7). Slide 8 demonstrates that the binary restenosis with direct stenting was similar and may be slightly better, particularly for the in­lesion binary restenosis compared with standard stent. Slide 9 demonstrates that the clinical events at 6 months were similar at less than 5% with either direct or standard stenting.

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