Development of the Cardiac Conduction System - Novartis by Novartis Foundation

By Novartis Foundation

The pacemaking and conduction process (PCS) is key for producing and synchronizing the center beat.  disorder of the program could be a direct explanation for cardiac conduction disturbance, arrhythmias and unexpected cardiac demise. A wealth of data has been gathered over a long time at the precise histological, morphological and phenotypic features of specialised cardiac tissues.  The mobile and molecular mechanisms that govern improvement of the desktops at the moment are growing understood.This e-book attracts jointly contributions from a global and interdisciplinary workforce of specialists engaged on either simple and medical elements of cardiac improvement. It positive factors experiences of the constitution and serve as of the constructing desktops, dialogue of the molecular and mobile mechanisms regulating embryological improvement of the program and studies at the basic foundation of desktops pathology.  The booklet additionally considers how novel healing interventions in accordance with knowing of the developmental biology of cardiac pacemaking and conduction tissues may possibly eventually influence on scientific medicine. 

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Sample text

Have you ever looked systematically at ectopically induced ¢bres? Do they always contain a pacemaker, node and Purkinje ¢bres, or can only one component of the conduction system be induced ectopically? Anderson: The question you are asking now relates to the point that Michael Rosen alluded to: in abnormal circumstances, ectopic rhythms can appear in any part of the myocardium. Under those circumstances, looking histologically would not permit us to identify the source of the rhythm. This would be like looking for a needle in a haystack.

Futura Publishing, Armonk, New York, p 269^279 Thompson RP, Lindroth JR, Wong YMM 1990 Regional di¡erences in DNA-synthetic activity in the preseptation myocardium of the chick. In: Clark EB, Takao A (eds) Developmental cardiology: morphogenesis and function. Futura Publishing, Armonk, New York, p 219^234 Timmermans C, Rodriguez LM, Medeiros A, Crijns HJ, Wellens HJ 2002 Radiofrequency catheter ablation of idiopathic ventricular tachycardia originating in the main stem of the pulmonary artery. J Cardiovasc Electrophysiol 13:281^284 Van Kempen MJA, Vermeulen JLM, Moorman AFM, Gros DB, Paul DL, Lamers WH 1996 Developmental changes of connexin40 and connexin43 mRNA-distribution patterns in the rat heart.

2). At the end the highly controversial issue of the internodal tracts is in place. The term ‘internodal tract’ has the same e¡ect to some as a red rag to a bull. In view of CHAMBER DEVELOPMENT 33 the cardiac building plan discussed above the region of the internodal tracts would be localized between the in£ow or sinoatrial region and the atrioventricular canal, and comprises the remaining part of the linear heart tube that has not developed into atrial chamber. Purposely, we have used the words out£ow and in£ow tract rather than the more conventional anatomical terms.

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