Drug Transporters (Handbook of Experimental Pharmacology, by Martin F. Fromm, Richard B. Kim

By Martin F. Fromm, Richard B. Kim

It really is more and more well-known that numerous transporter proteins are expressed through the physique and make sure absorption, tissue distribution, biliary and renal removal of endogenous compounds and medication and drug results. This booklet will supply an outline at the transporter households that are most vital for drug treatment. such a lot chapters will specialize in one transporter relations highlighting tissue expression, substrates, inhibitors, knock-out mouse types and scientific reports.

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Extra resources for Drug Transporters (Handbook of Experimental Pharmacology, Volume 201)

Example text

4 Inhibitors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Drug/Drug Interactions: Pharmacogenomics . . . . . . . . . . . . . . . . . . . . 88 10 Organic Anion Transporter 7 (OAT7, Gene Name SLC22A9) . . . . . . . . . . . . . 1 Cloning, Structure, Tissue Distribution, Localization . . . . . . . . .

2 Species Differences, Age and Gender Dependence of Expression; Abundance . . 3 Substrates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Inhibitors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Drug/Drug Interactions: Pharmacogenomics . . . . . . . . . . . . . . . . . . . . 88 10 Organic Anion Transporter 7 (OAT7, Gene Name SLC22A9) . . . .

90 Abstract Organic anion transporters 1-10 (OAT1-10) and the urate transporter 1 (URAT1) belong to the SLC22A gene family and accept a huge variety of chemically unrelated endogenous and exogenous organic anions including many frequently described drugs. OAT1 and OAT3 are located in the basolateral membrane of In Vitro and In Vivo Evidence of the Importance of Organic Anion Transporters (OATs) 31 renal proximal tubule cells and are responsible for drug uptake from the blood into the cells.

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