From Molecules to Networks, Third Edition: An Introduction by John H. Byrne, Ruth Heidelberger, M. Neal Waxham

By John H. Byrne, Ruth Heidelberger, M. Neal Waxham

An knowing of the worried procedure at almost any point of research calls for an knowing of its simple construction block, the neuron. The 3rd variation of From Molecules to Networks presents the forged beginning of the morphological, biochemical, and biophysical homes of nerve cells. in response to prior versions, the original content material specialize in mobile and molecular neurobiology and comparable computational neuroscience is maintained and greater.

All chapters were completely revised for this 3rd variation to mirror the numerous advances of the prior 5 years. the recent variation expands at the community points of mobile neurobiology via including new insurance of particular examine equipment (e.g., patch-clamp electrophysiology, together with purposes for ion channel functionality and transmitter unencumber; ligand binding; structural tools resembling x-ray crystallography).

Written and edited by means of top specialists within the box, the 3rd variation thoroughly and comprehensively updates all chapters of this particular textbook and insures that each one references to basic learn signify the newest results.

  • The first remedy of mobile and molecular neuroscience that incorporates an creation to mathematical modeling and simulation approaches
  • 80% up to date and new content
  • New bankruptcy on "Biophysics of Voltage-Gated Ion Channels"
  • New bankruptcy on "Synaptic Plasticity"
  • Includes a bankruptcy at the Neurobiology of Disease
  • Highly referenced, accomplished and quantitative
  • Full colour, expert snap shots throughout
  • All images are available digital model for instructing purposes

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Extra resources for From Molecules to Networks, Third Edition: An Introduction to Cellular and Molecular Neuroscience

Example text

PROTEIN SYNTHESIS IN NERVOUS TISSUE Both neurons and glial cells have strikingly extended morphologies. Protein and lipid components are synthesized and assembled into the membranes of these cell extensions through pathways of membrane biogenesis that have been elucidated primarily in other cell types. However, some adaptations of these general mechanisms have been necessary, due to the specific requirements of cells in the nervous system. Neurons, for example, have devised mechanisms for ensuring that the specific components of the axonal and dendritic plasma membranes are selectively delivered (targeted) to each plasma membrane subdomain.

Peripheral membrane proteins are localized on the cytoplasmic surface of the membrane and do not traverse any membrane during their biogenesis. , plateletderived growth factor receptor-Grb2-Sos-Ras complex). , myelin basic protein). A special case of membrane proteins are those anchored by lipid moieties such as glycan phosphatidyl inositol (Labasque and Faivre-Sarrailh, 2010) or palmitoylation (Fukata and Fukata, 2010), which include a number of signaling molecules. Integral Membrane and Secretory Polypeptides are Synthesized de Novo in the Rough Endoplasmic Reticulum The subcellular destinations of integral and peripheral membrane proteins are determined by their sites of synthesis.

The catalytic core of the proteasome is a barrel-shaped structure formed by four heptameric stacked rings, but additional proteins (about 16 polypeptides) may interact with the 20S core to form a larger 26S particle. , nonlysosomal pathways), they serve a number of important physiological functions, including regulation of cell proliferation and processing of antigens for presentation. In the nervous system, however, proteasomes are likely to be most important for homeostasis, allowing turnover of cytoplasmic polypeptides at specific sites so that the elaborate cellular extensions of neurons and glia may be maintained.

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