Intracellular Signal Transduction: The JAK-STAT Pathway by Andrew F. Wilks

By Andrew F. Wilks

This booklet is the 1st one written concerning the JAK/STAT pathway. The JAK (Janus Kinase) Protein tyrosine kinases are novel phosphotransferases totally required for mobile signalling downstream of non-catalytic cytokine receptors (amongst others). those molecules are parts in pathways applying the STAT (Signal Transducers and Activators of Transcription) transcription components. the elemental parts of the JAK/STAT pathway are coated intimately, and the centre piece of the ebook is a guided travel of the pathway itself. an enticing addition to the ebook is the bankruptcy at the use of Drosophila melanogaster as a genetic method to probe the pathway on the complete organism point. The booklet is concentrated to researchers who've an curiosity in intracellular signalling.

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Extra info for Intracellular Signal Transduction: The JAK-STAT Pathway (Molecular Biology Intelligence Unit)

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L. 0 Iii a 0 ..... ~ <;\" 3 ;><: );: ;! (1) Intracellular Signal Transduction: The JAK-STAT Pathway 54 Motif VIII JAKI JAK2 Tyk2 JAK3 EGF-R c-SRC DSPVFWYAPECL I ESPIFWYAPESL T DSPVFWYAPECL K QSPIFWYAPESL S KVPIKWMALESI L KFPIKWTAPEAA L Aside from this element, the JHI domains of each of the members of the JAK family are typical PTK domains. THE KINASE-LIKE (JH2) DOMAIN Based upon dadograms generated using programs such as Pile Up, the second kinase-related domain (JH2) is clearly ancestrally related to the broader family of kinase domains by virtue of the presence of most of the key kinase motifs defined by Hanks, Quinn and Hunter.

At present, the ligand binding chain for IL-13 has not been molecularly cloned, although some preliminary characterization of the subunit composition of its receptor has been carried out. 138,144 IL-2-Ra The human IL-2 Ra (also known as p55 or Tac) is a 272 amino acid transmembrane protein. 132 The extracellular domain is 219 amino acids in length, and is comprised of a single "Tac" domain, a feature which is not shared by any other cytokine receptor. The intracellular domain is very short-only 13 amino acids-and does not appear to possess any signaling capability.

F{,TTLi<:EIC~G:::. Rc:Q. ; 2 ·"2. ~'l H? 'Hl;,'Y:. Vt:i~~l. ::£S! f HGH9~"1tll ·: 1 . 'I'l. ",\ Kl:! v: .!. HG\o"C"\Ar. i'llrn(:H LVI>~'Ill 1': 1·C·\MTo<: );: ;! (1) Intracellular Signal Transduction: The JAK-STAT Pathway 54 Motif VIII JAKI JAK2 Tyk2 JAK3 EGF-R c-SRC DSPVFWYAPECL I ESPIFWYAPESL T DSPVFWYAPECL K QSPIFWYAPESL S KVPIKWMALESI L KFPIKWTAPEAA L Aside from this element, the JHI domains of each of the members of the JAK family are typical PTK domains.

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