Intravenous Immunoglobulins in Clinical Practice by Martin L. Lee

By Martin L. Lee

Spotting the explosive progress in info on intravenous immunoglobulins (IVIGs), this exhaustive single-source quantity surveys all on hand literature at the employment of IVIG arrangements in scientific perform from pharmacoeconomics and pharmacokinetics to prophylaxis and administration of infectious and autoimmune illnesses.

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Sample text

The apparent distribution volume and the total clearance were considered to be close to values observed in adults (33). 5 and 1 g/kg significantly increased IgG and group B streptococcal antibody levels for more than 14 days. From the terminal slope of the decay curve a T1/2 of 24 days was calculated (34). In a recent large trial Weisman et al. 5 g/L. The half-life calculated from data obtained 1, 2, and 8 weeks after infusion was 29 ± 20 days (35). 75 g/kg to two groups of very low-birth-weight neonates (36).

As expected, the increase of antibodies was most pronounced with the highest dose where the successive IVIG doses at monthly intervals induced a slight but not statistically significant increase of the preinfusion antibody titers. 75 g/kg to be sufficient to achieve and maintain a desired anti-RSV titer. There are a number of problems that may limit the validity of pharmacokinetic studies in newborns. First of all, newborns are not in steady-state conditions, even when IVIG is replaced at regular doses and intervals.

13. Janeway CA, Merler E, Rosen FS, et al. Intravenous gamma-globulin. Metabolism of gamma-globulin fragments in normal and agammaglobulinemic persons. N Engl J Med 1968; 278:919923. 14. Winkelhake JL. Immunoglobulin structure and effector functions. Immunochemistry 1978; 15:695714. 15. Pirofsky B. 25. Rev Infect Dis 1986; 8(suppl 4):457463. 16. Schiff RI. 25 immunoglobulin G intravenous preparations in patients with primary disorders of humoral immunity. Rev Infect Dis 1986; 8(suppl 4):449456.

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