Ion Channel Factsbook I: Extracellular Ligand-Gated Channels by Edward Conley, William J. Brammar

By Edward Conley, William J. Brammar

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Extra info for Ion Channel Factsbook I: Extracellular Ligand-Gated Channels (Factsbook)

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E. tending to reduce the open timer, open probabilityt or conductancet of the integral channel. XXX entry 02 Criteria for I N F O R M A T I O N RETRIEVAL sections This section should provide links to other sources of information about the ion channel type, particularly accession to sequence database, gene expression, structure-function and bibliographic resources operating over the Internett or available on CD-ROM. A full discussion of the potential scope for integration of these resources with molecular-based entries appears in Resource J - Search criteria & C S N development, entry 65.

Swtlpu, FASER J ( 19921 6 . 514-2,1. "iptcln, Trends N C I I ~ O(~I OLX'9I) 12: 265-70. Collingridgc, Trcnrls l'hrirrnncol Scl 4 1990) 11: 290-6. 1311ss, N ~ ~ i ~[l993) z r c 361:3l-9. ftarnsrd, Trends Riochern Sci ( 1992) 17: 36H-74. ' D~nglcd~nc, FASEIF (1900)4: 2 6 3 W S . Langnwh, Prou N n t l Aclrd Sci [JSA (19881 85:7,394-8. 3) 229: 1 101-24. II H u ~ a n l r ,Crrt H r v Nlochcm Mol fllr~l( l9K91 24. 183-21 5. I2 Hugantr, Nrrlrrjn [ I 9903 5 : 555-67. 3h. Maycr, I'rr)#qN~1~rol)tol l( 1987) 28: 197-276.

This appendix should describe a framework for describing how integrated sets of ion channel molecules (and their associated signalling components) have co-evolved for specific functions in terminally differentiatedt cell-types. To begin with, a tentative classification of functional cell types should be employed, used to cross-reference 'surveys' of ion channel expression wherever possible. This appendix should also contain available information pertaining to efficient and appropriate heterologous expression of ion channel genes in selected cell types, as this is often a limiting factor in biophysical characterization of clonedt ion channel cDNAt or gene products.

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