Lancet Infectious Diseases Volume 10, Issue 10, Pages by John McConnell

By John McConnell

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Additional info for Lancet Infectious Diseases Volume 10, Issue 10, Pages 653-736 (October 2010)

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Young children were more likely to be anaemic at presentation (28 [32%] of 87) than older children (26 [9%] of 298) and adults (16 [4%] of 423; RR 5·5; 95% CI 3·6–8·4; p<0·0001). On day 63, eight (1%) of 693 patients were moderately anaemic and 72 (10%) were mildly anaemic. The mean increase of haemoglobin was similar among the five treatment groups, was unaffected by intercurrent P vivax, but was slightly reduced by primaquine (0·75 g/dL vs 1·04 g/dL; p=0·036; mean difference 0·295 g/dL; 95% CI 0·199–0·570).

Table 1 shows the number and characteristics of new diagnoses by year, after multiple imputation and accounting for underreporting. Overall number of diagnoses decreased by an average of 3·7% per year from 2003 to 2008 (p<0·0001). 25% of new HIV diagnoses were classified as recent by the EIA-RI assay; this proportion did not vary during 2003–08 (table 1). MSM were the most commonly (40%) diagnosed during recent infection, compared with Frenchnational heterosexual women (28%) and men (22%), heterosexual non-French-national women (16%) and men (12%), and IDUs (15%).

17 We did a sensitivity analysis by simultaneously simulating different values of the false recency rate from 0% to 5% and proportions of repeat testers in new diagnoses from 20% to 80%. We assessed the robustness of incidence model results by comparison of the range of estimates within these extreme scenarios and 95% CIs. 1. Role of the funding source This study was supported by the French National Institute for Public Health Surveillance (InVS) and French National Agency for Research on AIDS and Viral Hepatitis (ANRS).

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