Management of rare adult tumours by Yazid Belkacemi, René-Olivier Mirimanoff, Mahmut Ozsahin

By Yazid Belkacemi, René-Olivier Mirimanoff, Mahmut Ozsahin

Why a publication devoted to infrequent melanoma management?

Given the big number of infrequent cancers,they soak up an important a part of our day-by-day perform. for that reason, we owe it to our sufferers with infrequent tumours that we use the data received within the remedy of the extra universal cancers to supply them with a greater destiny. this data comes from contemporary advancements in molecular diagnostics, systemic remedies with new medications and specified cures including complicated applied sciences within the parts of radiology and radiation remedy. Our authors have analysed the literature and suggest remedies for infrequent cancers in accordance with effects from earlier stories. we are hoping that this e-book could be an reduction to these treating infrequent melanoma instances approximately which, in past times, little has been released, and may reassure our sufferers that they've now not been forgotten.

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Moreover, surgery plays a major role in symptomatic treatment – a ventriculoperitoneal shunt can reduce the symptoms of intra-cranial hypertension. A complete work-up must be realised 2 weeks after surgery including craniospinal MRI, CSF fluid examination and bone scan in symptomatic patients. 8 to 2 Gy per fraction. – Boost to the posterior fossa delivering a dose of 20 Gy in 10 fractions. Radiation technique generally consists of: 1. posterior field (patient on supine position) for the vertex; 2.

Harris AE, Lee JYK, Omalu B et al. (2003) The effect of radiosurgery during management of aggressive meningiomas. Surg Neurol 60: 298-305 14. Ho D, Hsu C, Ting L et al. (2002) Histopathology and MIB-1 labeling index predicted recurrence of meningiomas. A proposal of diagnostic criteria for patients with atypical meningioma. Cancer 94: 1538-47 15. Hug EB, Devries A, Thornton AF et al. (2000) Management of atypical and malignant meningiomas: role of high dose, 3D-conformal radiation therapy. J Neurooncol 48(2): 151-60 16.

The results of combination chemotherapy have been described in a small series but hydroxyurea has been more often used in patients presenting a benign or aggressive meningioma, with both favourable [24,40] and unfavourable outcomes [21,30]. Overall, there is no convincing evidence on the efficacy of drug treatments for intracerebral or metastatic recurrence; inclusion in multicentre, prospective trials is desirable. Therapeutics targeting epidermal growth factor (EGF), vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) are under evaluation.

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