Medical Management of Chronic Myelogenous Leukemia (Basic by Moshe Talpaz, Hagop Kantarjian

By Moshe Talpaz, Hagop Kantarjian

This worthy reference presents a well timed precis of present remedies for persistent myelogenous leukemia (CML), discussing either easy pathophysiology and new experimental strategies.
Combining the insights of over 30 renowned researchers within the box, scientific administration of power Myelogenous Leukemia

  • compares interferon treatment with traditional chemotherapy
  • covers persistent, speeded up, and Philadelphia-negative levels
  • details typical remedy with IFN- regimens and allogenic stem mobile transplantation
  • describes the application and barriers of CML animal versions
  • profiles medical trials checking out IFN together with different brokers
  • assesses advancements in survival instances between CML sufferers
  • reviews the effectiveness of Southern blot tracking
  • traces the improvement of oligonucleotides as strength healing brokers
  • outlines remedy with monoclonal antibodies, specified NK cells, and immune T cells
  • and extra!
    Containing over 1500 references, tables, drawings, and pictures, scientific administration of continual Myelogenous Leukemia is appropriate for scientific oncologists, hematologists, immunologists and researchers within the fields of tumor immunology and melanoma immunotherapy, internists, and citizens, fellows, and scientific college scholars in those disciplines.
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    Extra resources for Medical Management of Chronic Myelogenous Leukemia (Basic and Clinical Oncology)

    Example text

    In most studies, achieving minimal hematologic (CHR) or cytogenetic tu­mor burden correlated with survival prolongation (Table 8). In two studies that failed to show this prognostic association, a low rate of major cytogenetic re­sponse rate was noted, possibly because of low doses of IFN-α administered (Table 7). Two studies showing a correlation between cytogenetic response and survival also reported that patients on IFN-α therapy who did not achieve a cytogenetic response resulted in equivalent survival as conventional chemother­apy (20,25).

    Anderson Cancer Center Experience 303 Claire F. Verschraegen 15. Monitoring the Course of Chronic Myelogenous Leukemia by Fluorescence In Situ Hybridization 317 Chu-Myong Seong, Hagop M. Kantarjian, Moshe Talpaz, Richard Champlin, and Michael Siciliano Page vii 16. Molecular Monitoring of CML During Interferon Treatment: Insights from the Cancer and Leukemia Group B Experience 327 Wendy Stock Developmental Therapies17. Oligonucleotide Therapeutics for Chronic Myelogenous Leukemia 341 Alan M. Gewirtz 18.

    Patients with lymphoid blastic phase often have CALLA-positive, myeloid marker-positive disease and respond to ALL therapy (CR rate 50% to 60%); their median survival is better than myeloid or undifferentiated cases (9 months versus 3 months) (64). A cytogenetic clonal evolution has been considered a criterion for acceler­ation. A recent analysis suggests that its prognostic effect depends on the spe­cific abnormality, its predominance in marrow metaphases, and the time of ap­pearance (65). Patients with chromosome 17 abnormalities, ≥25% abnormal metaphases, clonal evolution >25 months after diagnosis, and no prior therapy with IFN-α have the worst outcome.

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