Molecular Basis of Membrane-Associated Diseases by E. Van Obberghen, R. Ballotti, Y. Le Marchand-Brustel, J. C.

By E. Van Obberghen, R. Ballotti, Y. Le Marchand-Brustel, J. C. Scimeca (auth.), Prof. Dr. Angelo Azzi, Prof. Zdenek Drahota, Prof. Sergio Papa (eds.)

Biological membranes are frequently effected by way of illnesses. Molecular occasions resulting in or bobbing up from pathological adjustments during assorted ailments are as but now not in actual fact understood. This useful examine by way of top specialists covers adjustments of the mobile atmosphere, membranes and the metabolic capabilities in the course of tissue development and differentiation in addition to facets of irregular organelle functionality in lysosomal garage ailments, peroxisomal and mitochondrial problems, enzyme defects and regulatory defects of receptors as a result of oncogenes.

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CeI147:545-554 Johnson EM Jr, Rich KM, Yip HK (1986) The role ofN G F in sensory neurons in vivo. Trends N eurosci 1:33-37 Konkol RJ, Mailman RB, Bendeich EG, Garrison AM, Muel1er RA, Breese GR (1978) Evaluation of the effects of nerve growth factor and anti-nerve growth factor on the development of central catecholaminergic neurons. Brain Res 144:277-285 Korsching S (1986) Nerve growth factor in the central nervous system. Trends Neurosci 11/12:570-573 Korsching S, Thoenen H (1983) Nerve growth factor in sympathetic ganglia and corresponding target organs of the rat: correlation with density of sympathetic innervation.

Accordingly, the same size bcr-abl mRNA is detected in blast crisis and chronic phase cells. Quantitatively, the amount of the bcr-abl mRNA present in the two phases of the disease varies considerably between CML patients, and the level of expression does not correlate with the stage of the disease (Gale and Canaani 1984). In the majority of patients additional chromosomal abnormalities are detected during blast crisis (Champlain and Golde 1985). This probably leads to the activation of other genes which, superimposing their effects upon the Ph' genetic defect, may promote the transition into blast crisis and determine whether the disease will evolve into a myeloid or lymphoid acute phase.

Cuello and Sofroniew 1984) and these innervated areas exhibit relatively high levels ofNGF and NGF-mRNA as compared to other brain regions (Korsching et al. 1985; Whittemore et al. 1986; Shelton and Reichardt 1986). In analogy to the situation in the peripheral nervous system, there is a close correlation between the levels ofNGF and its mRNA and the density of cholinergic innervation. g. the CA3, CA4 and dentate gyrus region have higher levels of NGF protein compared with the CA1-CA2 region and this is reflected in the density of cholinergic innervation (cf.

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