Myb Transcription Factors: Their Role in Growth, by Jon Frampton

By Jon Frampton

This quantity represents the 1st selection of articles contributed by way of examine leaders engaged on the Myb kinfolk of transcriptional regulatory proteins. in additional than twenty chapters the authors speak about the variety of organic procedures and various mobile varieties during which Myb proteins function. even supposing targeting the 3 vertebrate Myb kinfolk, homologues from reduce species also are mentioned end result of the mild they may be able to shed at the evolution and serve as of those proteins. person chapters describe the involvement of Myb proteins, specifically c-Myb, in basic and diseased improvement and serve as of many tissues together with haemopoietic cells, blood vessels, the gastrointestinal tract and the mind. numerous chapters discover the mechanistic information of the motion of Myb proteins, specially structural gains, their interplay with DNA and different regulatory proteins, and the diversity of genes which are regulatory goals for this staff of transcription components. This paintings should be of curiosity to these operating without delay within the box and likewise to the broader study neighborhood investigating the transcriptional legislation of improvement, differentiation and development. The healing power of manipulating Myb functionality is usually mentioned making the e-book attractive to clinician scientists in different fields together with haematology, oncology and cardiology.

Show description

Read or Download Myb Transcription Factors: Their Role in Growth, Differentiation and Disease (Proteins and Cell Regulation) PDF

Similar hematology books

Killer Lymphocytes

This generally documented, finished survey of cell-mediated cytotoxicity (CMC) strains the historical past of killer lymphocytes from 1960 to the current, supplying a definitive source for experts and non-specialists alike. It bargains a sophisticated research of CMC, together with a complete exam of key papers underlying its evolution, and gives an intensive dialogue of the newest advances within the box.

Molecular Hematology 3rd ed.

Now in its 3rd version, Molecular Hematology has been completely up-to-date to include contemporary advances in molecular study. the purpose of the ebook continues to be an identical – to supply a middle wisdom base for people with little publicity to molecular organic concepts. Molecular biology has had an important impression at the realizing of blood illnesses and this booklet indicates how molecular suggestions can be utilized in analysis and therapy.

Wintrobe's Clinical Hematology, 2-Vol. Set

Demonstrated seeing that 1942 because the top hematology textbook, Wintrobe's scientific Hematology is now in its completely revised 12th version. The textual content keeps its culture of correlating easy technological know-how with the medical perform of hematology and is equipped to aid physicians locate medical solutions quick and simply.

Non-Hodgkin Lymphoma: Pathology, Imaging, and Current Therapy (Cancer Treatment and Research)

This booklet presents scientific practitioners and the learn neighborhood with designated details at the analysis, diagnosis, and therapy of non-Hodgkin lymphoma, making an allowance for the numerous development in wisdom together with a number of healing advances which have been accomplished over the last 5-10 years.

Additional resources for Myb Transcription Factors: Their Role in Growth, Differentiation and Disease (Proteins and Cell Regulation)

Sample text

1997) TRF1 is a dimer and bends telomeric DNA. EMBO J. 16, 1785-1794. , Markus, J. and Wolff, L. (2002) Covalent attachment of the SUMO-1 protein to the negative regulatory domain of the c-Myb transcription factor modifies its stability and transactivation capacity. J. Biol. Chem. 277, 8999-9009. M. and Gilson, E. (1996) The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human. Nucl. Acids Res. 24, 1294-1303. M. L. (2002) Essential role for the SANT domain in the functioning of multiple chromatin remodeling enzymes.

1999) Cohabitation of insulators and silencing elements in yeast subtelomeric regions. EMBO J. 18, 2522-2537. L. S. (1996) FAETL motif required for leukemic transformation by vMyb. J. Virol. 70, 5600-5610. , Ramsay, G. L. (2002) Mutations in Drosophila myb lead to centrosome amplification and genomic instability. Development 129, 347-359. A. and Kohler, N. (1999) Discovery of tetraploidy in a mammal. Nature 401, 341. Ganter, B. S. (1999) Myb and oncogenesis. Adv Cancer Res 76, 21-60. Garcia-Fernandez, J.

2004 Kluwer Academic Publishers. Printed in the Netherlands. 2 C. Davidson, E. Ray and J. Lipsick invertebrates (Drosophila), invertebrate chordates such as sea urchin (Stongylocentrotus purpuratus) and Ciona intestinalis, bony fish (Fugu and Zebrafish), amphibians (Xenopus), birds (chicken) and mammals (human, mouse and cow). Interestingly, not all animals possess 3R myb genes; analysis of the completely sequenced genome of the free-living nematode C. elegans indicates a 3R myb gene does not occur in this organism.

Download PDF sample

Rated 4.19 of 5 – based on 17 votes