By H. Joachim Deeg, David T. Bowen, Steven D. Gore, Torsten Haferlach, Michelle M. Le Beau, Charlotte Niemeyer
The analysis of myelodysplastic syndromes (MDS), a heterogeneous team of clonal hematopoietic issues, is being made with expanding frequency during the last decade due to elevated attractiveness, superior knowing, and an getting older inhabitants. This publication, thoroughly up-to-date because the first version, summarizes in a concise and targeted means the present wisdom of all points of MDS. medical presentation, etiology, epidemiology, molecular biology, type, and staging are all mentioned. transparent suggestions is supplied on prognosis and differential prognosis, and remedy recommendations are defined intimately, together with management of hematopoietic development components, biologically dependent therapy, hematopoietic stem mobilephone transplantation, and supportive care. extra bankruptcy is dedicated to MDS in little ones. This essentially orientated ebook might be of price to a large spectrum of scholars and practitioners within the field.
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Extra resources for Myelodysplastic Syndromes (Hematologic Malignancies)
The studies of MDS have relied either on self-reported pesticide exposure, which is subject to recall bias in retrospective studies, or exposure assigned according to occupational title, which offers little information on the level of exposure or types of pesticides used. A study conducted in an agricultural region of Greece asked comparatively detailed questions about pesticide use history (Kokouva et al. 2011). 8). 1) (Kokouva et al. 2011). Additional information supporting pesticides as potentially causal for MDS are epidemiologic associations with other myeloid cell malignancies.
Bjork et al. 3 % increased risk of MDS per pack-year of exposure, amounting to an excess risk of 71 % (95 % CI = 3–180) associated with 40 pack-years of smoking (Bjork et al. 2009). Several studies evaluated risk factors for subgroups of MDS cases classified by histologic subtype or chromosomal abnormalities. One study found that RAEB/RAEB-t patients were more likely to be current smokers than RA/RARS patients (18 % vs. 10 %) (Strom et al. 2005) and that MDS patients with chromosomal abnormalities were more likely to be ever smokers than those with normal karyotype (73 % vs.
3) Medium/high exposure (vs. 5) Resultsa Pesticides 2 Epidemiology and Etiology 27 Reference Lv et al. J. 1) Other significant associations No education (vs. 0) 2 Epidemiology and Etiology 29 30 2001; Strom et al. 2005). 7), with evidence of heterogeneity of the effect between studies but no evidence of publication bias (Du et al. 2010). Ma et al. 4) (compared to never smokers) and increased by the number of packs per day (Ma et al. 2009). Bjork et al. 3 % increased risk of MDS per pack-year of exposure, amounting to an excess risk of 71 % (95 % CI = 3–180) associated with 40 pack-years of smoking (Bjork et al.