By Barbara J. Bain, Estella Matutes
Assembly the desires for haematologists and medical chemists for an up to the moment reference, this atlas presents a visible presentation of myeloproliferative neoplasms and myeloid leukaemia. Compiled via prime specialists within the united kingdom, every one person affliction is surveyed through bankruptcy, overlaying the medical presentation, haematological and pathological positive aspects, immunophenotyping and cytogenetic and genetic abnormalities. prognosis and differential prognosis is mentioned, and analysis and treatment plans are reviewed. The e-book is seriously illustrated all through with color images and diagrams. This atlas fills a spot within the literature and is a vital source for all haematologists. Its spouse quantity within the sequence contains an illustrated advisor to lymphoid malignancies.
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Extra resources for Myeloid Malignancies: An Atlas of Investigation and Diagnosis
However, other than proving that a case is myeloid, immunophenotyping is not essential for the application of the WHO classification. The WHO classification is hierarchical. Cases are assigned to categories in the order shown in the following paragraphs. Therapy-related AML The 2001 WHO classification recognized two broad groups of therapy-related AML although some overlap occurs [13–15]. In the 2008 classification the two categories have been amalgamated. g. g. lomustine), platinum-based agents (carboplatin, cisplatin) and exposure to radiation is characterized by a latent phase of 5–10 years, preceding MDS, trilineage myelodysplasia and an association with abnormalities of chromosomes 5 and 7 (–5, 5q–, –7, 7q–) and with complex chromosomal abnormalities.
Mast cell disorders are a group by themselves rather than being recognized as a MPN in the 2001 classification but in the 2008 classification are grouped with other MPN. With advancing knowledge of the molecular mechanisms underlying chronic haematological neoplasms, the three broad groups of MPN, MDS and MDS/MPN may prove constricting. Cases with the same molecular abnormality will sometimes fall into the MPN category and sometimes into the MDS/MPN group. The next decade is likely to see a reappraisal of the basis of our classifications.
2005). Therapy-related leukemia: clinical characteristics and analysis of new molecular risk factors in 96 adult patients. Leukemia, 19, 1919–1928. 16 Bloomfield CD, Archer KJ, Mrozek K, Lillington DM, Kaneko Y, Head DR et al. (2002). 11q23 balanced chromosome aberrations in treatment-related myelodysplastic syndromes and acute leukemia: report from an international workshop. Genes, Chromosomes Cancer, 33, 331–345. 17 Slovak ML, Bedell V, Popplewell L, Arber DA, Schoch C, Slater R et al. (2002).