Myocardial Protection by Tomas A. Salerno, Marco Ricci

By Tomas A. Salerno, Marco Ricci

Myocardial security is considered probably the most very important, but additionally such a lot debatable features of cardiac surgical procedure. there was massive development in myocardial safeguard ideas over fresh years, employing various new methods to regard cardiac illnesses, and this article is meant to include the state-of-the-art during this box.

The booklet summarises the nation of data on all elements of myocardial security, together with the newest within the therapy of cardiac ailments, robotics, pediatric surgical procedure and the remedy of cardiac failure. robot surgical procedure, valvular surgical procedure, pediatric surgical procedure and coronary surgical procedure are all coated through popular specialists, generating a entire, forward-looking view of the sphere of myocardial security. This booklet may still functionality to replace physicians and surgeons drawn to the sphere of cardiac surgical procedure at the present kingdom of information on myocardial protection.

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Example text

It has been additionally reported that LPC might directly increase sarcolemmal permeability to Ca2+ and increase nonselective cation currents for Na+, K+, and Ca2+. All of these effects demonstrate that LPC is an arrhythmogenic agent. In addition, LPC accumulation in cardiac myocytes augments the activity of PLA2 via a positive feedback mechanism [61-64]. In light of the above mentioned results a pharmaceutical agent possessing antiphospholipase activity would render protection against ischemia-reperfusion damage.

Clin Invest 1996; 98:2854-65. 130 Bergman MR, Holycross BJ. Pharmacological modulation of myocardial tumor necrosis factor alpha production by phosphodiesterase inhibitors. / Pharmacol Exp Ther 1996; 279:247-54. 131 Vandenabeele P, Declercq W, Vanhaesebroeck B, Grooten J, Fiers W. Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells. JImmunol 1995; 154:2904-13. 132 Abraham E, Bursten S, Shenkar R et al. Phosphatidic acid signaling mediates lung cytokine expression and lung inflammatory injury after hemorrhage in mice.

In conclusion, the mechanisms modulating ischemic preconditioning include alterations in antioxidant 20 defence [27], stimulation of adenosine Aj receptors, activation of PKC, activation of phospholipase D, induction of heat shock proteins, reduction in TNFa production, attenuation of the development of intracellular acidosis, and prevention of the intracellular Ca2+ overload [18,19,23]. The existing evidence strongly favors preconditioning as an effective intervention of ischemia-reperfusion injury.

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