Neonatal Hematology by Pedro de Alarcón, Eric Werner, Robert D. Christensen

By Pedro de Alarcón, Eric Werner, Robert D. Christensen

Neonatal hematology is a fast-growing box, and hematologic difficulties ensue within the majority of ill neonates. targeting scientific matters and problem-solving, it is a totally revised and up to date revision of a profitable useful advisor to the pathogenesis, popularity and administration of hematologic difficulties within the neonate. the second one version starts with chapters at the background of neonatal hematology, hematopoiesis, and the immunologic procedure. next sections are dedicated to erythrocyte issues, platelet issues, leucocyte problems, immunologic issues and hemostatic problems. New to this version are an improved assurance of neonatal oncology, wire blood usage, neonatal screening, prenatal prognosis and hyperbilirubinemia. Written by way of training physicians focusing on pediatric hematology, neonatology, immunology, pediatric infectious illness and transfusion medication, this is often an important textual content for pediatric hematologists, NICU experts, neonatologists and neonatal nurse practitioners.

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In Spain, a prospective study identified 1 of 60 infants with perinatal parvovirus infection to have parvovirus-related fetal loss [227]. In contast, Miller and colleagues [231] described an excess rate of fetal loss of 9% for women infected with parvovirus in the first 20 weeks of pregnancy. In this group, there were seven cases of fetal hydrops, all in weeks 11–18 of gestation. There was no increased risk of adverse outcomes for women infected after the twentieth week. Thus, the likelihood of a fetus developing nonimmune hydrops as a result of maternal parvovirus infection is small, especially after 20 weeks of gestation.

Maternal infection is often asymptomatic. Even if the characteristic chancres appear, they may be non-painful and hidden from sight. Maternal screening serologies performed early in pregnancy will miss infection later in gestation. Placental abnormalities, such as the presence of plasma cells, may suggest the diagnosis of maternal infection. The Red Book: 2003 Report of the Committee on Infectious Diseases from the American Academy of Pediatrics notes that no newborn should be discharged from the hospital without determination of the mother’s serologic status for syphilis and that testing of cord blood or infant sera is inadequate for screening [163].

However, serious sequelae, such as paralytic Disorders of the fetomaternal unit polio, may occur. Enterovirus is most prevalent in the summer and the fall. While most cases of enteroviral infection in the newborn are self-limited, serious infection may occur [217]. Infection can occur through transplacental passage, contact with the virus in the passage through the birth canal, and postnatal exposure. Several nursery epidemics have been reported with different enteroviruses [216]. Symptoms of neonatal enterovirus infection vary widely.

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