By David S. Goodsell
Molecular Nature is a richly illustrated consultant to the extreme range of molecules which are liable for existence. David Goodsell, writer of the highly-praised booklet, The equipment of existence, has synthesized an unlimited volume of information in a fashion that's available to the overall reader. Molecular Nature examines themes starting from the form of cells to the molecules liable for digestion, immunity, and idea. The author's targeted mixture of medical and inventive abilities make this a readable, stimulating and hugely evocative e-book. About the Author: David Goodsell is within the division of Molecular Biology on the study Institute of Scripps sanatorium in l. a. Jolla, California. His study contains special effects and X-ray crystallography. he's the writer of The equipment of lifestyles (Springer-Verlag, 1992), and his art has been proven at exhibitions on technology and artwork.
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The writer offers a easy creation to the area of genetic engineering. a few two decades have handed because the first recombinant DNA molecules have been developed at Stanford collage. Genetic engineering is now a fact and this publication easily and concisely describes to the coed the whole diversity of allowing applied sciences on hand.
In 1809 -- the 12 months of Charles Darwin's start -- Jean-Baptiste Lamarck released Philosophie zoologique, the 1st complete and systematic thought of organic evolution. The Lamarckian technique emphasizes the iteration of developmental adaptations; Darwinism stresses choice. Lamarck's rules have been ultimately eclipsed by means of Darwinian thoughts, in particular after the emergence of the trendy Synthesis within the 20th century.
Epigenetics is taken into account by way of many to be the "new genetics" end result of the overwhelming facts of the contribution of non-genetic components equivalent to foodstuff, surroundings, and chemical publicity on gene expression. the results of epigenetics are substantial, together with tissue/organ regeneration, X-chromosome inactivation, and stem mobile differentiation and genomic imprinting and getting older.
The issues e-book is helping scholars take pleasure in the ways that experiments and easy calculations can result in an figuring out of ways cells paintings by way of introducing the experimental origin of mobilephone and molecular biology. each one bankruptcy stories keyword phrases, checks for figuring out uncomplicated suggestions, and poses research-based difficulties.
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Additional info for Our Molecular Nature: The Body’s Motors, Machines and Messages
Glucose, however, does not have the taste that consumers prefer, so it is converted to sweeter fructose by application of bacterial d-xylose isomerase. Enzymes are remarkable machines, and like machines of our familiar world, they are often the focus of industrial entrepreneurs . o-Xylose isomerase is but one example. Digestive enzymes have found use in laundry detergents, chewing away nasty stains, and in cleaning solutions for contact lenses. Other digestive enzymes, purified in large quantities from bacteria, curdle milk into cheese.
A similar class of proteinases, termed cysteine proteinases, use the sulfur atom in a cysteine amino acid to perform a cleavage reaction, in place of the oxygen atom in a serine. Tiny digestive compartments inside each of our cells, termed lysosomes, contain the cysteine proteinases cathepsin B and cathepsin H, as well as dozens of other digestive enzymes. Inside lysosomes, old proteins are digested and their amino acids are recycled to build new proteins. Two cysteine proteinases made by plants may be found in the local grocery store.
The difference between a poison and a drug is the identity of the victim. If our own ribosomes are attacked, the compound is a poison; if the smaller ribosomes of bacteria fall victim, the compound will be useful as an antibiotic drug. Chloramphenicol, tetracycline, and streptomycin fall in the latter category, attacking bacterial ribosomes and leaving our larger ribosomes unharmed. Unfortunately, they may also, attack the smaller ribosomes in our mitochondria, leading to unwelcome side effects.