By Jonathan R. Kerr M.D., Susan F. Cotmore, Marshall E. Bloom M.D., R. Michael Linden, Colin R. Parrish
This finished reference paintings brings jointly for the 1st time details on each element of the parvoviruses in one quantity. It offers the hot approach of parvovirus type, as agreed by way of the foreign Committee for the Taxonomy of Viruses (ICTV), and contains leading edge info at the virology, molecular and mobile biology, immunology and scientific manifestations of an infection with every one recognized and proposed family member Parvoviridae. The e-book additionally describes the quickly increasing easy and scientific technological know-how which underpins gene remedy purposes utilizing helper-dependent and helper-independent parvoviruses. The revered editorial crew has drawn jointly popular participants from world wide to provide what is going to absolutely develop into the traditional reference at the topic. it really is crucial examining for medical or study virologists and microbiologists, infectious affliction experts, and public healthiness experts and laboratories.
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This entire reference paintings brings jointly for the 1st time details on each point of the parvoviruses in one quantity. It offers the hot method of parvovirus type, as agreed by means of the overseas Committee for the Taxonomy of Viruses (ICTV), and contains innovative info at the virology, molecular and mobile biology, immunology and scientific manifestations of an infection with every one identified and proposed family member Parvoviridae.
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Knowledge of the receptors and crystal structures of the different AAV isolates give us a framework to begin to assess the newer AAV isolates with regard to their potential usefulness in gene therapy applications. Further, the diversity of the newer isolates gives us so much more ‘ready-made’ information to choose from in the rational design of new and hopefully better gene therapy vectors. Deciphering this information is a primary focus of many laboratories. 1) has been problematic but it is clearly necessary to shift through the redundant isolates in order to propel 18 Genus Dependovirus the field forward.
Serology, a method classically used to group viruses, is no longer in vogue in the AAV field as it has become obvious that there are not 124 distinct AAV serotypes. The AAV isolates can and do fall into serologically distinct ‘groups’. For example, Li and Samulski (unpublished data) have determined that the AAV1 and AAV6 capsids that differ by only six amino acids are serologically similar. , 2002, 2003, 2004). One could not envision each of these as unique antigenic sites. Because of the inherent problems with the use of serotypes for classification, the AAV field is now moving away from its use and examining alternative classification systems.
Journal of Virology 75: 2729–40. , Plantevine, G. and Atger, P. 1964. Virose d’un type habituel chez le Lepidoptere, Galleria mellonella L. Revue de Zoologie Agriculture Appliqué 63: 207. Neuwald, A. , Spouge, J. L. and Koonin, E. V. 1999. AAAϩ: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Genome Research 9: 27–43. Rose, J. , Berns, K. , Hoggan, M. D. and Koczot, F. J. 1969. Evidence for a single-stranded adenovirus-associated virus genome: formation of a DNA density hybrid on release of viral DNA.