Polyamine Cell Signaling: Physiology, Pharmacology, and by Jian-Ying Wang

By Jian-Ying Wang

Polyamines are natural cations present in all eukaryotic cells and in detail curious about, and required for, unique organic services. An expanding physique of facts shows that the legislation of mobile polyamines is a important convergence element for the a number of signaling pathways riding numerous mobile capabilities. over the past decade, enormous development has been made in und- status the molecular features of mobile polyamines. those major findings offer a basic foundation not to basically outline the precise position of polyamines in body structure, but in addition to advance new healing techniques for cancers and different ailments. the key goal of this booklet is to supply a well timed and durable advisor for investigators within the fields of polyamines, body structure, pharmacology, and melanoma learn. it is going to supply a starting place according to examine and deal with the possibility of next functions in medical perform. Polyamine mobilephone Signaling: body structure, Pharmacology, and melanoma examine is split into 4 major elements: half I: Polyamines in sign Transduction of phone Proliferation half II: Polyamines in mobile Signaling of Apoptosis, Carcinogenesis, and melanoma remedy half III: Polyamines in mobilephone Motility and Cell–Cell Interactions half IV: Polyamine Homeostasis and delivery This e-book not just covers the present cutting-edge findings proper to mobile and molecular services of polyamines, but additionally offers the underlying conceptual foundation and data relating to power healing concentrating on of polyamines and polyamine metabolism. those issues are addressed via int- nationally famous specialists of their contributions to this booklet.

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Additional info for Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research

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Curr. Drug Targets 7, 565–585. 20. Edwards, M. , Prakash, N. , Stemerick, D. , et al. (1990) Polyamine analogues with antitumor activity. J. Med. Chem. 33, 1369–1375. 21. Edwards, M. , Snyder, R. , and Stemerick, D. M. (1991) Synthesis and DNA-binding properties of polyamine analogues. J. Med. Chem. 34, 2414–2420. 22. Porter, C. W. and Sufrin, J. (1986) Interference with polyamine biosynthesis and/or function by analogues of polyamines or methionine as a potential anticancer chemotherapeutic strategy.

In response to these findings, three additional compounds were synthesized that possessed substituents containing the intervening ring sizes (CBENSpm, CPENTSpm, and CHEXENSpm), as shown in Fig. 10. All three analogs were generally cytotoxic in both the H157 and H82 cell lines, but there was no correlation between the induction of SSAT and the IC50 value in the H157 line, as shown in Fig. 11. 7 µM). These data clearly support the contention that there are at least two mechanisms by which unsymmetrically substituted alkylpolyamines produce cytotoxicity in H157 non-SCLC cells.

The ubiquitous nature of the polyamines, and the wide variety of effects they produce, virtually guarantees that new polyamine effector sites will be discovered, and that these sites will provide new avenues for drug design and development. References 1. Bergeron, R. , McManis, J. , Weimar, W. , et al. (1995) The role of charge in polyamine analog recognition. J. Med. Chem. 38, 2278–2285. 2. Cohen, S. A. ) (1998) Guide to the Polyamines. Oxford University Press, New York. 3. Sunkara, P. , Baylin, S.

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