Regulatory RNAs, 1st Edition by Bruce Stillman, David Stewart

By Bruce Stillman, David Stewart

"Regulatory RNAs" was once the topic of the 71st annual chilly Spring Harbor Symposium on Quantitative Biology, the place scientists from around the globe awarded the most recent advances within the biology of RNAs, together with RNA interference, transcriptional and translational regulate, RNA modifying, and the function of RNAs in organic circuits and epigenetic occasions. Investigators mentioned the most recent applied sciences geared toward large-scale characterization of RNAs, in addition to the jobs of small RNAs in improvement and melanoma. This quantity is a well timed survey of this crucial new sector of molecular biology.

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Qxd 14 2/6/07 2:49 PM Page 14 BAULCOMBE cursor is an RNA with partially complementary internal repeats (Fig. 2). The inverted repeat regions anneal to form an incompletely double-stranded RNA in which mismatched regions in the RNA precursor are likely to provide structural cues that guide Dicer to a single site in the precursor RNA. It is also possible that these mismatch sites exclude DCL from the flanking regions so that each precursor normally gives rise to only a single sRNA (Han et al. 2006).

Down-regulation of porins by a small RNA bypasses the essentiality of the RIP protease RseP in E. coli. J. Biol. Chem. 281: 12253. A. and Touati D. 2004. Hfq, a new chaperoning role: Binding to messenger RNA determines access for small RNA regulator. EMBO J. 23: 396. Gottesman S. 2004. The small RNA regulators of Escherichia coli: Roles and mechanisms. Annu. Rev. Microbiol. 58: 273. _______ . 2005. Micros for microbes: Non-coding regulatory RNAs in bacteria. Trends Genet. 21: 399. , and Bateman A.

These isoforms share a common second-largest subunit, but they have largest subunits with different carboxy-terminal domains. From the siRNA phenotype of RNA silencing mutants, it seems that pol IV provides a template RNA that is converted into dsRNA by an RDR and then into siRNA by a DCL (Herr et al. 2005; Pontier et al. 2005). These mutant phenotypes also indicate that sRNA production by pol IVb is dependent on pol IVa but not vice versa (Pontier et al. 2005). A plausible mechanism that explains this interdependence is similar to the amplification of tasiRNAs: A primary siRNA produced in a pol IVa pathway would cleave a pol IVb transcript so that it becomes a template for dsRNA production by an RDR.

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