Stem Cells and Human Diseases by Brahma N. Singh, Sharmila Shankar, Rakesh K. Srivastava

By Brahma N. Singh, Sharmila Shankar, Rakesh K. Srivastava (auth.), Rakesh Srivastava, Sharmila Shankar (eds.)

The major aim of this booklet is to supply a entire assessment on stem cells and their position in tissue regeneration, homeostasis and treatment. moreover, the position of melanoma stem cells in melanoma initiation, development and drug resistance are mentioned. The mobilephone signaling pathways and microRNA regulating stem telephone self-renewal, tissue homeostasis and drug resistance also are pointed out. total, those experiences will offer a brand new knowing of the impact of stem cells in tissue regeneration, disorder legislation, remedy and drug resistance in different human diseases.

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Morrison SJ, Qian D, Jerabek L, Thiel BA, Park IK, Ford PS, Kiel MJ, Schork NJ, Weissman IL, Clarke MF (2002) A genetic determinant that specifically regulates the frequency of hematopoietic stem cells. J Immunol 168:635–642 67. Muranyi AL, Dedhar S, Hogge DE (2010) Targeting integrin linked kinase and FMS-like tyrosine kinase-3 is cytotoxic to acute myeloid leukemia stem cells but spares normal progenitors. Leuk Res 34:1358–1365 68. Murga M, Jaco I, Fan Y, Soria R, Martinez-Pastor B, Cuadrado M, Yang SM, Blasco MA, Skoultchi AI, Fernandez-Capetillo O (2007) Global chromatin compaction limits the strength of the DNA damage response.

As the pathophysiology differs in PD, ALS, MS and stroke, different cell sources for transplantation might be required for optimal clinical improvement. Elementary examination is compulsory before stem cell transplantation therapy can become a realistic clinical treatment. Recently, the overall goal for many laboratories in their research became to understand the function of human brain stem cells and how they may play a role in the origin of brain tumors. Understanding the relationship between the genesis of brain tumors and the potential interventions using stem cells are of greatest importance and has been also recently a topic for many publications.

Intravenous injection of HUCBCs reduced leukocyte infiltration into the brain [54], although it is not clear whether this is a direct effect on the inflammatory response or a secondary effect attributable to reduction in infarct size. It seems paradoxical that a xenotransplant would inhibit the immune response. However, there is evidence in the literature that stem cells can directly inhibit T-cell activation [54]. 7 Recruitment of Endogenous Progenitors Endogenous neurogenesis is increased after stroke.

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