By Christine A. Lee, Erik E. Berntorp, W. Keith Hoots
The Textbook of Hemophilia has develop into a definitive source for all these coping with hemophilia sufferers. It covers the entire universal and infrequent bleeding problems, either when it comes to medical administration in addition to the genetic, laboratory, monetary and mental features.
This moment version covers the entire most recent advancements within the box of hemophilia, with new chapters on:
- the genetic and molecular foundation of inherited blood disorders
- how to regulate adolescent and older patients
- emergency drugs and inherited blood disorders
- national hemophilia databases
Drawing at the significant event of the authors, the purpose of this textbook continues to be a similar - to enhance the care of sufferers being affected by hemophilia. The publication is filled with exact suggestions and suggestion on daily scientific questions making it valuable to all trainee and working towards hematologists.
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Extra info for Textbook of Hemophilia
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Biochemistry 1992; 31(13): 3315–25. 45 Higuchi M, Wong C, Kochhan L, et al. Characterization of mutations in the factor VIII gene by direct sequencing of amplified genomic DNA. Genomics 1990; 6(1): 65–71. 46 Rand MD, Kalafatis M, Mann KG. Platelet coagulation factor Va: the major secretory platelet phosphoprotein. Blood 1994; 83(8): 2180–90. 47 Kalafatis M, Rand MD, Jenny RJ, Ehrlich YH, Mann KG. Phosphorylation of factor Va and factor VIIIa by activated platelets. Blood 1993; 81(3): 704–19. 48 Ganz PR, Tackaberry ES, Palmer DS, Rock G.
Recently however, a mutation altering a furin cleavage site in canine FVIII was shown to result in increased FVIII activity that was attributed to increased stability, possibly a consequence of reducing dissociation of the heavy and light chains . These observations have contributed to interest in developing single chain FVIII protein for therapeutic use in hemophilia . Summary Eukaryotic cells contain an extensive machinery to modify polypeptides that transit the secretory compartment.