By Marion E. Reid
The second one version of The Blood staff Antigen FactsBook offers key info on the subject of human crimson blood telephone membrane elements wearing blood crew antigens, the molecular foundation of the antigens, their serological features, and the scientific value of blood team antibodies. the knowledge in this team of molecules has increased drastically because the prior variation was once released 5 years in the past. issues contain: historical past and knowledge on terminology, expression, chromosomal task, service molecule description, molecular foundation of antigens, influence of enzymes/chemicals, medical value, disorder organization, phenotypes, glycotypes and key references.
- Over 250 totally up to date entries on blood team antigens, formatted on unmarried pages for simple use
- Inclusion of RHAG blood team procedure and over twenty new antigens
- Basic technological know-how paired with scientific purposes to provide context to information
- Full-color illustrations, gene maps and charts
- Both conventional and ISBT-sanctioned naming conventions integrated
Read Online or Download The Blood Group Antigen FactsBook, Second Edition PDF
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Additional info for The Blood Group Antigen FactsBook, Second Edition
361, 895–906. Dahr, W. (1986) In: Recent Advances in Blood Group Biochemistry (Vengelen-Tyler, V. J. eds) American Association of Blood Banks, Arlington, VA, pp. 23–65. A. et al. (1985) Transfusion 25, 274–277. Long, A. et al. (2002) Immunohematology 18, 120–122. Hil and some Rhnull Molecular basis associated with s antigen1 Amino acid Thr 29 Nucleotide C at bp 143 in exon 4 In addition to Thr 29, some anti-s also require Thr 25 (and/or GalNAc attached to this residue), Glu 28, His 34 and Arg 352.
Molecular basis associated with Mc antigen1 O-glycosylation of residues 2, 3 and 4 is normal. 48 MNS blood group system 1 NH2 Ser1 Ser Thr Thr Glu5 GP(A-B-A) RBC lipid bilayer 131 COOH Variant glycophorin Gene arrangement Mechanism GPAM(1–4)-GPB(5)-GPA(6–131) GYP(A-B-A) Gene conversion Comments No alloanti-Mc has been described. Mc is defined by the reaction of defined anti-M and anti-N: a majority of anti-M and a minority of anti-N react with Mcϩ RBCs. -H. O. -P. and Rouger, P. eds) Plenum Press, New York, pp.
R. (2001) Immunohematology 17, 76–81. Daniels, G. (2002) Human Blood Groups, 2nd Edition, Blackwell Science, Oxford. M. et al. (1996) Transfusion 36, 362–374. Daniels, G. (1999) Blood Rev. 13, 14–35. J. et al. (1991) Transf. Med. Rev. 5, 108–113. H. (1994) Proc. Natl. Acad. Sci. USA 91, 2415–2419. Tippett, P. et al. (1992) Transf. Med. Rev. 6, 170–182. Dahr, W. et al. (1991) Biol. Chem. Hoppe-Seyler 372, 573–584. 001) M, identified in 1927, was the first antigen of the MNS system; named after the second letter of “immune” because antiM was the result of immunizing rabbits with human RBCs Occurrence Caucasians Blacks 78% 74% Antithetical antigen N (MNS2) Expression Cord RBCs Altered 34 Expressed On some hybrid glycophorin molecules MNS blood group system Molecular basis associated with M antigen1 GPA NH2 1 Ser1 Ser Thr Thr Gly5 RBC lipid bilayer 131 COOH Nucleotide C at bp 59, G at bp 71 and T at bp 72 in exon 2 Recognition of antigen by anti-M is usually dependent on O-glycans attached to amino acid residues 2, 3 and 4.