The Chemokine System in Experimental and Clinical Hematology by Oystein Bruserud

By Oystein Bruserud

The purpose of the difficulty is to explain and clarify the significance of the chemokine method in hematology. The chemokine process is perhaps very important for plenty of features of ordinary in addition to malignant hematopoiesis. a huge concentration is the advance and remedy of hematologic malignancies, together with the immunobiology of stem telephone transplantation. the current stories illustrate that chemokines could be fascinated about leukemogenesis. The chemokine method is usually very important either for the crosstalk among malignant cells and their neighbouring nonmalignant stromal cells (including endothelial cells) in addition to for immunoregulation in sufferers handled with allogeneic stem mobilephone transplantation. hence, chemokines are vital either for the pathogenesis and remedy of hematological ailments.

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Example text

Also, during infection, the milieu is overwhelmed with high concentrations of cytokines and chemokines secreted as a result of infection. These mediators ought to activate NK cells; hence, it is important to study activated NK cells that lyse both abnormal cells as well as microbially infected cells, and which secrete mediators that regulate both innate and adaptive immune cells. 1 NK Cell Distribution into Various Tissues Although NK cells are mainly present in the blood circulation, these cells migrate into inflammatory sites, particularly upon infection.

50 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 Abstract Natural killer (NK) cells represent a major subpopulation of lymphocytes. These cells have effector functions as they recognize and kill transformed cells as well as microbially infected cells. In addition, alloreactive NK cells have been successfully used to treat patients with acute myeloid leukemia and other hematological malignancies.

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