Thomas' Hematopoietic Cell Transplantation by Karl G. Blume, Stephen J. Forman, Frederick R. Appelbaum

By Karl G. Blume, Stephen J. Forman, Frederick R. Appelbaum

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An crucial source for all hematologists, oncologists, pathologists, pediatricians, immunologists and all others drawn to this dynamic sector of medicine!

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  • Extensive insurance of topic sector - from the clinical foundation to the view of the future
  • Includes all experimental learn and scientific application
  • Combined the information and services of over one hundred seventy overseas specialists
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  • Over 500 illustrations, together with a color plate section

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Sample text

In 1999, the use of HCT for breast cancer declined dramatically and in 2001 breast cancer accounted for <5% of autotransplants in North America. Treatment of solid tumors still accounts for about 15% of autotransplants (Fig. 2) (Statistical Center of the IBMTR and ABMTR, unpublished data). In 1996, a randomized trial comparing high-dose therapy and autologous HCT with conventional therapy for multiple myeloma indicated a significant survival benefit with autotransplantation [23]. Autologous HCT for myeloma increased dramatically after this report; multiple myeloma now accounts for 30–40% of autotransplants (Fig.

Cavins et al. [32] showed that canine marrow could be cryopreserved by freezing in dimethylsulfoxide (DMSO), thawed and injected intravenously without removal of the DMSO. This technique was to become standard for autologous marrow transplantation. Goodman and Hodgson [33] had shown that mice could be protected against lethal irradiation by infusion of blood cells. Cavins et al. [34] showed that autologous canine buffy coat cells from the peripheral blood could be collected, cryopreserved in DMSO and infused after lethal irradiation with subsequent recovery of marrow function.

In November 1968 Gatti et al. [53] performed the first successful allogeneic graft in a patient with severe combined immunodeficiency. Two similar successes were reported immediately thereafter [54,55]. All three patients were alive and well 25 years later [56]. In late 1967 the Seattle marrow transplantation team received a grant to support clinical marrow transplantation. , who were to be dedicated to patients undergoing intensive therapy and marrow transplantation with a special emphasis on post-transplant clinical care.

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